See Rome’s iconic amphitheatre and walk through the Roman Forum to get a sense of ancient Rome; book tickets in advance — sites typically open 8:30am–7:00pm in September.
Stroll from the Colosseum area (via Largo di Torre Argentina/Pantheon if you like) to the Trevi Fountain and Spanish Steps for classic Rome photo stops; open and free 24/7.
Classic Roman dishes (cacio e pepe, carbonara) in an authentic Trastevere trattoria; very popular — reservations recommended, typically open evenings from ~7:00pm.
Reserve timed tickets for the Vatican Museums — open 9:00am–6:00pm (last entry tends to be earlier). The Sistine Chapel and Raphael Rooms are highlights; plan 2.5–3 hours.
Visit St. Peter’s Basilica (open roughly 7:00am–6:30pm) and consider climbing the dome for sweeping views (fee applies; check opening times for dome climb).
Quick hotel breakfast or grab-and-go coffee and cornetto; confirm airport transfer or train schedule to allow recommended arrival 2–3 hours before intercontinental flights.
Take the Leonardo Express (approx 30–35 minutes) or prebook a private transfer depending on luggage and comfort; trains run early but check schedule for your flight time.