Morning: Land at San Francisco International Airport and take the BART to downtown. Drop your bags at the hotel and freshen up before heading out.
Afternoon: Explore Fisherman's Wharf and its lively atmosphere, then wander to Pier 39 to watch the sea lions and browse the boutique shops.
Evening: Dine on fresh seafood at a wharf restaurant and enjoy a sunset walk along the waterfront with views of the Bay Bridge.
Find HotelsMorning: Ride a historic Cable Car up the hills to Union Square, where you can shop and admire the public art.
Afternoon: Walk down to the famous Lombard Street, then head to Coit Tower for panoramic city vistas.
Evening: Stroll through Chinatown, sampling dumplings and exploring the vibrant markets before returning to your hotel.
Find HotelsMorning: Bike or walk across the majestic Golden Gate Bridge, stopping at the vista points for photos.
Afternoon: Take a ferry to Alcatraz Island, touring the historic prison and learning its fascinating stories.
Evening: Return to the city for dinner at Ghirardelli Square, indulging in chocolate desserts.
Find HotelsMorning: Journey to Muir Woods National Monument to walk among ancient redwoods.
Afternoon: Continue to the charming waterfront town of Sausalito for lunch and boutique shopping.
Evening: Head back to San Francisco and relax with a sunset view from the Marina District.
Find HotelsMorning: Depart for Napa Valley, beginning with a tasting at Domaine Carneros.
Afternoon: Visit Castello di Amorosa for its impressive castle setting and wine pairing.
Evening: Return to San Francisco, perhaps enjoying a light dinner in the Mission District.
Find HotelsMorning: Check out of your San Francisco hotel and catch a flight to Las Vegas.
Afternoon: Arrive, check into your resort on The Strip, and explore the nearby casino lounges.
Evening: Watch the spectacular Bellagio Fountain show and dine at a themed restaurant.
Find HotelsMorning: Stroll along The Strip, popping into iconic venues like Caesars Palace and the Paris Las Vegas Eiffel Tower.
Afternoon: Ride the High Roller Observation Wheel for sweeping desert city views.
Evening: Experience the neon glow at the Neon Museum and enjoy a nightcap at a rooftop bar.
Find HotelsMorning: Drive to Red Rock Canyon for scenic drives and easy hikes among striking sandstone formations.
Afternoon: Picnic in the park and take a guided nature walk to learn about local flora and fauna.
Evening: Return to the city for a relaxed dinner and perhaps catch a show on The Strip.
Find HotelsMorning: Take a day trip to the engineering marvel of Hoover Dam, exploring its visitor center.
Afternoon: Continue to Lake Mead for a boat ride or lakeside stroll.
Evening: Head back to Las Vegas for a final night of entertainment, perhaps at Fremont Street Experience.
Find HotelsMorning: Enjoy a leisurely breakfast at the hotel and take a final walk along The Strip for last‑minute photos.
Afternoon: Check out and transfer to the airport for your flight home.
Evening: Arrive back home with wonderful memories of San Francisco and Las Vegas.
Find HotelsIf you have extra time, add an extra day in San Francisco to visit the Exploratorium or take a day trip to Santa Cruz. In Las Vegas, consider extending your stay by a night to enjoy a spa day or a helicopter tour over the Grand Canyon. To shorten the trip, combine Day 4 and Day 5 by taking a condensed wine tour, and skip the evening visit to the Mob Museum, focusing instead on the main attractions of The Strip.