From Václav Havel Airport, leave around 8:45 a.m. and take public transport toward Hotel U Prince in Old Town. The Airport Express is simplest if luggage is manageable, while bus 119 to Nádraží Veleslavín, followed by Metro A to Staroměstská, is usually cheaper; allow 45–60 minutes. Ask the hotel to store your bags if the room is not ready. Start at Old Town Square and Prague Astronomical Clock—the hourly procession is brief, so arrive a few minutes before the hour and then spend time around the square’s lanes rather than lingering in the busiest center.
Walk south toward Café Louvre for a late breakfast or coffee in its elegant, historic dining room. It generally opens from early morning, and a simple breakfast or coffee-and-dessert stop should cost roughly 150–350 CZK per person. From there, return toward the center to climb Powder Tower; check the day’s opening hours before setting out, as October hours are shorter than summer hours. The climb is worth it for the compact rooftops-and-spires view, though the staircase is narrow.
Continue next door to Municipal House, one of Prague’s finest Art Nouveau buildings. If an interior tour is running, it is the best way to see the decorated salons; otherwise, admire the entrance and café spaces, with tour prices commonly several hundred CZK. After a relaxed lunch break nearby, walk into Josefov for the Old Jewish Cemetery and Spanish Synagogue. Allow about two hours for the combined Jewish Quarter visit, and dress respectfully; the sites are covered by a combined ticket rather than a single inexpensive standalone admission. October afternoons become dim early, so aim to arrive by about 2:30–3:00 p.m. Finish with an unhurried walk along the quiet lanes around Maiselova Street and Pařížská Street, then return to Hotel U Prince for a rest or an affordable dinner away from the square, where prices are notably higher.
Leave Hotel U Prince around 8:00 a.m. and walk to Národní třída for Tram 22 toward Pražský hrad; the ride takes roughly 15–25 minutes. Buy a 30-minute ticket through the PID Lítačka app or at the stop—about 30 CZK—and validate a paper ticket before boarding. Start at Prague Castle around opening time, allowing about three hours for St. Vitus Cathedral, the Old Royal Palace, and Golden Lane. Go first to the cathedral, when tour groups are thinner; castle grounds are free, but the main circuit requires a ticket, generally around 450 CZK, with reduced tickets available. Wear comfortable shoes, as the complex is spread across cobbled courtyards and inclines.
Walk about 10 minutes through Hradčany to Loreto, a beautifully quiet Baroque complex where an hour is enough for the church, cloisters, and treasury; check the official schedule before setting out, as October hours can be limited and admission is usually around 200 CZK. Continue another 15 minutes uphill to Strahov Monastery for its famous library halls and sweeping city views. The library interiors are viewed from the doorway, but the monastery grounds and nearby beer hall make this a good unhurried stop; allow about an hour. From here, descend through Malá Strana—roughly 25 minutes, with excellent views along Nerudova Street—to Malostranské náměstí, spending 45 minutes admiring the Baroque façades and side lanes. This downhill route is much more pleasant than retracing your tram journey.
Have an early Czech dinner at U Glaubiců, a historic cellar restaurant just off Malostranské náměstí. Reserve if possible, or arrive around 5:00 p.m.; expect roughly 300–550 CZK per person for a main course and drink. Try svíčková, goulash, or a simple schnitzel, and check the bill before paying since service may be listed separately. After dinner, walk five minutes to Kampa Park and spend the evening beside the river, looking back toward Charles Bridge and the illuminated Old Town waterfront. The park is free and open at all hours; from Kampa, it is about a 15-minute walk back to Hotel U Prince, or you can continue to Újezd for trams if your feet need a break.
Start from Malá Strana around 8:30 a.m. and walk across Charles Bridge, continuing along Národní třída to Wenceslas Square. Allow 30–40 minutes with photo stops; the bridge is much calmer before 9 a.m. Spend about 45 minutes taking in the long boulevard, the Wenceslas Monument, and the surrounding historic façades. Then enter the National Museum, which usually opens at 10 a.m.; allow roughly two hours for its grand interior and historical collections. Admission is generally around 300 CZK, with reduced tickets sometimes available, and the building is a good rainy-day stop.
Walk approximately 15 minutes through Jungmannovo náměstí and Melantrichova to Havelský Market. Browse the fruit, baked goods, and inexpensive snacks, but compare prices before buying souvenirs—some stalls are aimed squarely at visitors. For a quick lunch, pick up something simple here or nearby, keeping 45 minutes for the market. Continue about 20 minutes toward Náplavka Farmers’ Market on Rašínovo nábřeží; depending on the weekday schedule and weather, the riverside stalls may be limited in October, so have a nearby café as a backup. Plan 200–400 CZK per person for a relaxed food stop, and enjoy the river views rather than rushing.
After lunch, take Tram 7 or 14 from the embankment area toward Výtoň, then walk uphill for 10–15 minutes to Vyšehrad. Give yourself about two hours to explore the fortress walls, Basilica of St. Peter and St. Paul, Vyšehrad Cemetery, and the viewpoints over the Vltava. The grounds are free; the basilica and cemetery-related interiors may charge a modest admission. Leave by 4:30–5:00 p.m. From Vyšehrad, take Metro C from Vyšehrad station or a taxi toward your Prague departure point; allow 60–90 minutes to reach the airport, plus extra time to collect luggage. Before leaving, the streets around Výtoň are convenient for one last inexpensive coffee or takeaway.