Agoura Hills is conveniently located just off of the 101 freeway, so driving to most points of interest is relatively straightforward. Car rentals will run around $30-$50 a day depending on the type of car and time of year. The Metrolink Train also runs from Agoura Hills to Downtown LA for $15 per ride. Be sure to check the Metrolink schedule ahead of time.
If you have extra time, consider taking a day trip to Santa Barbara, which is a scenic drive up the Pacific Coast Highway. Also, be sure to pack sunscreen and plenty of water for outdoor activities. If you have less time, you can cut down the itinerary by choosing only the activities that most appeal to you.
The closest airport to Agoura Hills is the Los Angeles International Airport (LAX), which is approximately 30 miles away.