Start the day at the Royal Palace of Naples with its baroque architecture and picturesque interiors. Then head over to the Castel dell'Ovo with its stunning views of the bay of Naples. End the day with a visit to the Naples National Archaeological Museum, showcasing classical sculptures and mosaics.
Take a guided tour by boat of the Amalfi Coast, stopping at picturesque destinations Positano and Amalfi. Stroll along the colorful buildings of Positano before enjoying the local seafood. Explore hand-made crafts in Amalfi and unwind at the Spiaggia del Fornillo Cassiopea beach.
Begin today visiting Pompeii, a UNESCO World Heritage Site, and immerse yourself in the history and architecture of the city that was buried by Mt. Vesuvius's eruption in 79 AD. Afterwards, head towards Mount Vesuvius, where you can take a hike to the summit and enjoy the magnificent views of the Bay of Naples and the surrounding volcanic fields.
Take a flight to the historic city of Catania, located on Sicily's east coast. Visit the Roman Amphitheater that is nearly 2000 years old, end the day visiting the 18th-century city centre, highlighted by the Piazza del Duomo with its exquisitely designed Cathedral.
Visit the ancient Greek Theater of Taormina, that dates back to 3rd century BC, known for its breathtaking views of Mount Etna and the Mediterranean Sea. Walk down the Corso Umberto and enjoy some local delicacies such as arancini and cannoli. End the day at Isola Bella, the pearl of the Ionian Sea, and relax on the pebble beaches.
Visit the ancient Dyonisus Cathedral and the Neapolis Archaeological Park to explore Greek ruins of a bygone era. Visit the island of Ortigia, the heart of Syracuse, filled with ancient castles, narrow lanes, street markets and cafes. Later, enjoy the sunset views along the stunning Mediterranean coastline at the Porto Piccolo of Siracusa.
If you have more time, consider adding a visit to the Capodimonte Museum in Naples, where you can admire priceless works of Italian art. Alternatively, you can spend an extra day exploring the coast villages such as Ravello or Praiano. If you have less time, consider skipping Pompeii or reducing your time in Catania.