Spend your morning exploring the stunning landscape of the Saguaro National Park East. This park is home to the world's largest cacti and is a great spot for hiking, photography, and birdwatching.
El Charro Cafe is the oldest Mexican restaurant in the United States and serves up delicious traditional dishes. Try their carne seca or the shrimp tacos for a taste of the local cuisine.
The Arizona-Sonora Desert Museum is a combination of a zoo, botanical garden, and natural history museum. You can see desert animals, including wolves, mountain lions, and Gila monsters. They also have a hummingbird aviary, butterfly garden, and cactus garden.
Also known as the White Dove of the Desert, Mission San Xavier del Bac, is a historic Spanish Catholic mission. This stunning church is a National Historic Landmark and has stunning frescoes, sculptures, and paintings.
End your day with dinner at Old Pueblo Grille, which offers Mexican fare and margaritas. Try their signature dish, chiles en nogada, it's a stuffed poblano pepper with a walnut cream sauce.
If you have more time, consider visiting the Biosphere 2, an ecological research center, or the Reid Park Zoo, home to over 500 animals. If you have less time, skip the Arizona-Sonora Desert Museum and head straight to Mission San Xavier del Bac. Remember to bring plenty of water and sunscreen as it can get hot in the desert!