Mesa is best explored by car. Consider renting a vehicle at Phoenix Sky Harbor International Airport. The estimated travel time between the airport and Mesa is 30 minutes. The estimated cost for a one-day car rental is $50-75, depending on the type of vehicle you choose. During peak season, traffic in the Phoenix area can be heavy, so plan accordingly.
If you have more time, consider visiting the Mesa Arts Center or the Arizona Museum of Natural History. If you have less time, skip the hike at Usery Mountain Regional Park and opt for a shorter walk at the Riparian Preserve at Water Ranch. Additionally, if you have a sweet tooth, check out Super Chunk Sweets & Treats or Petersen's Old-Fashioned Ice Cream for a sugary treat.