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5-Day Road Trip Itinerary from San Francisco, CA to Lafayette, LA with Daily 12-Hour Drives

Viewed by 88 travelers

Day 1: West to Nevada

San Francisco, CA to Las Vegas, NV on June 15, 2025

7:00am

Breakfast at Mama’s on Washington Square

Start your trip with a hearty breakfast at Mama’s, famous for its delicious omelets and French toast. It opens at 7 AM, perfect to energize before a long drive.
USD25, 1h

8:00am

Drive from San Francisco to Las Vegas

Begin your approximately 10-11 hour drive covering around 570 miles heading southeast through California and Nevada to reach Las Vegas.
USD0, 11h

7:00pm

Dinner at Lotus of Siam

Enjoy one of Las Vegas’ top-rated Thai restaurants, known for its authentic Northern Thai cuisine, perfect after a long day of driving.
USD40, 1.5h
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Day 2: Nevada to Texas

Las Vegas, NV to Amarillo, TX on June 16, 2025

6:30am

Breakfast at The Bagel Cafe

Grab fresh bagels and a coffee at this popular local spot before another long day on the road. Opens at 6 AM.
USD15, 0.5h

7:00am

Drive from Las Vegas to Amarillo

Drive approximately 750 miles eastbound through Arizona, New Mexico, and into Texas, targeting Amarillo for your evening stop.
USD0, 12h

7:30pm

Dinner at Tyler's Barbeque

Savor authentic Texas BBQ dishes in Amarillo, renowned for their smoked meats and sides.
USD30, 1h
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Day 3: Texas to Louisiana

Amarillo, TX to Lafayette, LA on June 17, 2025

6:00am

Breakfast at Yellow City Street Food

Enjoy a quick and flavorful breakfast featuring locally inspired dishes before your final stretch eastward. Opens at 6 AM.
USD20, 0.5h

6:30am

Drive from Amarillo to Lafayette

Travel approximately 820 miles through Dallas, TX, then onward east into Louisiana, arriving in Lafayette by evening.
USD0, 12h

7:00pm

Dinner at Prejean’s Restaurant

Celebrate arrival with Cajun cuisine at Prejean’s, a Lafayette staple known for its gumbo and jambalaya.
USD35, 1.5h
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Day 4: Lafayette Culture

Lafayette, LA on June 18, 2025

8:00am

Breakfast at The French Press

Try creative breakfast options with a Cajun twist at this popular Lafayette cafe, opening at 7 AM.
USD18, 1h

9:30am

Vermilionville Historic Village

Explore this living history museum showcasing Acadian, Native American, and Creole cultures of the region. Open 9 AM to 5 PM.
USD12, 2h

12:00pm

Lunch at Randol’s Restaurant

Enjoy traditional Cajun dishes like crawfish étouffée in a warm setting.
USD25, 1h

1:30pm

Acadian Cultural Center

Visit exhibits on Cajun heritage and music. Open 9 AM to 4 PM.
USD8, 1.5h

4:00pm

Le Parc Cinema or Relax in Downtown Lafayette

Catch an indie film at this charming local cinema or stroll around the downtown area.
USD12, 2h

7:00pm

Dinner at The French Press

Return for a refined dinner featuring locally sourced ingredients and inventive Cajun flavors.
USD45, 1.5h
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Day 5: Lafayette Leisure

Lafayette, LA on June 19, 2025

8:00am

Breakfast at Sage Bakehouse

Pick up fresh pastries and coffee at this artisanal bakery open from 7 AM.
USD12, 0.5h

9:00am

Day at Girard Park

Enjoy a relaxing morning walk or picnic in Lafayette’s largest park, with gardens, playgrounds, and walking trails.
USD0, 2h

11:30am

Lunch at Blue Dog Café

Dine on live music and eclectic Cajun-inspired dishes in a friendly atmosphere.
USD30, 1h

1:00pm

Shopping at Cajun Country Store

Browse crafts, spices, and souvenirs showcasing local culture.
USD0-USD50, 1h

2:30pm

Quick snack or coffee at Black Water Coffee

Enjoy a refreshing beverage or snack before concluding your trip. Open till 5 PM.
USD10, 0.5h
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