Start with a strong Panamanian coffee and a light breakfast (pan con bistec or pastry). Café Unido locations usually open by 7–8am and are a great introduction to local beans.
Watch ships pass through the Pacific locks, visit the museum and observation decks; Miraflores is typically open 9:00am–5:00pm and is a must-see to understand the Canal's scale and history.
Explore exhibits on Panama's biodiversity and the isthmus' role in species exchange; the Biomuseo is typically open ~10:00am–5:00pm and is on the Amador peninsula for an easy transfer.
Wander UNESCO-listed Casco Antiguo streets, plazas and churches; shops and galleries are usually open until early evening and the neighborhood offers great sunset photo opportunities.
Choose rooftop dining for modern Panamanian cuisine and skyline views; these restaurants commonly open for dinner from around 6:00pm—reserve in advance if possible.
Finish the evening on a rooftop terrace for cocktails and views of the city lights; many bars stay open late, perfect for a relaxed first-night sendoff.
Drive (~30–45 minutes from central Panama City) to the Gamboa area—this is the gateway for boat wildlife tours on Gatun Lake and forest walks; leave early for best wildlife sightings.
Guided boat tour exploring Gatun Lake, wildlife viewing (howler monkeys, birds), and a stop at Monkey Island; many operators run tours 8:30–10:00am departures, and morning is prime for sightings.
Lunch with rainforest views at the resort—simple, fresh lunches available and it’s convenient after a morning on the water; kitchen hours typically cover midday.
Zipline or tram through the rainforest canopy to see treetop wildlife and enjoy a different perspective; most activities run 1:00–4:00pm and last 1–2 hours, book ahead for space.
Casual seaside dinner: try fresh ceviche or fried seafood at the Fish Market—open day into evening (roughly 8:00am–8:00pm) and ideal for an authentic local meal.
Catch a public ferry (multiple departures morning-to-afternoon) to Taboga Island; schedules vary but morning ferries (~8:30–10:00am) are common and the crossing is ~30–45 minutes.
Relax on the main beach (Playa Restinga) and hike to the Cristo Rey viewpoint for island panoramas; island trails and beaches are open all day and make for a leisurely morning.
Catch an afternoon ferry back to the mainland (mid-afternoon sailings common); aim to return by mid- to late-afternoon for the city's final activities.
Quick hike to the city viewpoint for skyline and city forest contrast; the park is open early morning to around 5:00–6:00pm (confirm local hours) and hikes take 45–90 minutes.
End with a signature Panamanian tasting menu — Maito is one of Panama City's top restaurants and typically opens for dinner from ~6:00pm; reserve in advance.
Return to your hotel to collect luggage or transfer to Tocumen Airport if you have an evening flight—allow 30–60 minutes for airport transfer depending on traffic.