Start at Duomo di Milano when it opens—on a Saturday in late November, aim for around 8:00–9:00, though exact hours and rooftop access vary, so reserve a timed ticket online. Allow about two hours for the cathedral, archaeological area, and rooftop; the rooftop is especially worthwhile in crisp autumn weather, with views toward the Alps when visibility is good. Expect roughly €15–€25 depending on whether you choose stairs or the lift, and dress modestly for entry. Afterwards, wander straight into Galleria Vittorio Emanuele II, just beside the cathedral, for 30–45 minutes beneath its famous glass-and-iron roof. Look for the mosaic bull on the floor—spinning on its heel is a Milanese good-luck ritual—and take the short walk to Luini on Via Santa Radegonda for a panzerotto. It is a quick, inexpensive lunch at about €5–€10 per person; queues move quickly, but it is primarily takeaway, so eat nearby rather than expecting a leisurely restaurant meal.
Walk north through the compact center to Teatro alla Scala, about five minutes from Luini. The museum usually opens from late morning into the afternoon, but access to the auditorium can be restricted during rehearsals or performances, so check the official schedule and buy a museum ticket in advance if this is a priority; allow about an hour. From La Scala, continue through Brera’s elegant lanes to Pinacoteca di Brera, roughly 10–15 minutes on foot. Reserve a timed entry—Saturday afternoons are busy—and spend up to two hours with works by Raphael, Caravaggio, and Mantegna. The gallery generally closes in the early evening, with adult admission around €15; leave a little time to stroll Via Brera and the surrounding side streets before heading onward.
Finish at Bar Basso in Città Studi, reached from Brera by tram or metro in roughly 20–30 minutes; the M2 from Lanza toward Piola is usually the simplest option, followed by a short walk. Arrive around 18:00–19:00 for a classic Milanese aperitivo and order the Negroni Sbagliato, said to have been created here. Drinks are generous and run about €15–€25 per person; this is a lively, old-school bar rather than a formal dinner stop, so consider it a pre-dinner drink and check its Saturday hours before setting out.