In the morning, start at The Vatican Museums (9 am to 4 pm) to see the Sistine Chapel and other Renaissance artworks. In the afternoon, visit St. Peter's Basilica (7 am to 7 pm) for a breathtaking view of the city from the dome, then head to the Spanish Steps (9 am to 7 pm) for a picturesque view of the city and great nearby shopping.
Visit The Colosseum (9 am to 7 pm) and the Roman Forum (8:30 am to 7 pm) in the morning. Next, visit The Pantheon (9 am to 7 pm) and then walk down Via del Corso for some window shopping and people-watching.
Start with a morning coffee in the charming neighborhood of Trastevere, then visit the beautiful Santa Maria in Trastevere (7:30 am to 12 pm, 4 pm to 8 pm), followed by a stroll around the shops and cafes. In the afternoon, make your way to the Jewish Ghetto for an immersive cultural experience, complete with delicious cuisine and historical landmarks such as the Great Synagogue of Rome (10 am to 5 pm).
Start with a relaxing breakfast at one of the cafes in Piazza Navona then visit the beautiful Sant'Agnese in Agone church (9 am to 1 pm) before exploring the square's beautiful fountains and architecture. In the afternoon, head over to the Borghese Gallery (9 am to 7 pm, closed on Mondays) to view some of the world's most beautiful art collections in a stunning 17th-century villa.
Begin your day at the magnificent Castel Sant'Angelo (9 am to 7:30 pm) which used to be a mausoleum, then a castle, and now a museum. In the afternoon, end your trip with a walk along Via Condotti, Rome's most exclusive shopping street, and make sure to check out the Spanish Academy of Rome's palace (9 am to 7 pm).
If you have more time, consider adding a day trip to the nearby towns of Tivoli or Frascati. If you have less time, consider cutting out some of the less essential sites such as the Jewish Ghetto or Via Condotti. Remember to book tickets in advance to save time, especially for the Vatican Museums and Colosseum. Be aware that many shops and restaurants close for a few hours in the afternoon for siesta, but stay open later in the evening.