Day 1: Rome
Estimated travel time/distance from previous location: N/A
Colosseum, Roman Forum, Pantheon
Day 2: Vatican City
Estimated travel time/distance from previous location: 30 minutes (2.5 miles) from Rome
Sistine Chapel, St. Peter's Basilica, Vatican Museums
Day 3: Florence
Estimated travel time/distance from previous location: 2 hrs 30 mins (143 miles) from Vatican City
Ponte Vecchio, Uffizi Gallery, Il Duomo di Firenze
Day 4: Pisa
Estimated travel time/distance from previous location: 56 minutes (49 miles) from Florence
Leaning Tower of Pisa, Baptistery, Piazza dei Miracoli
Day 5: Cinque Terre
Estimated travel time/distance from previous location: 2 hrs 40 mins (97.9 miles) from Pisa
Scenic hikes, charming villages, Ligurian Sea
Day 6: Milan
Estimated travel time/distance from previous location: 3 hrs (138 miles) from Cinque Terre
Il Duomo di Milano, Sforza Castle, Leonardo da Vinci's Last Supper
Day 7: Lake Como
Estimated travel time/distance from previous location: 48 minutes (30 miles) from Milan
Lakeside villas, funicular ride, scenic views
Day 8: Verona
Estimated travel time/distance from previous location: 2 hrs (93 miles) from Lake Como
Juliet's Balcony, Verona Arena, Piazza delle Erbe
Day 9: Venice
Estimated travel time/distance from previous location: 1 hr 45 mins (75 miles) from Verona
Grand Canal, St. Mark's Basilica, Doge's Palace
Day 10: Bologna
Estimated travel time/distance from previous location: 2 hrs (100 miles) from Venice
Archaeological Museum, Basilica di San Petronio, Piazza Maggiore
Day 11: Tuscany
Estimated travel time/distance from previous location: 2 hrs 30 mins (97 miles) from Bologna
Vineyards, charming towns, Pisaqale Terme thermal baths
Day 12: Naples
Estimated travel time/distance from previous location: 4 hrs (277 miles) from Tuscany
Pompeii, National Archaeological Museum, Mount Vesuvius
Day 13: Amalfi Coast
Estimated travel time/distance from previous location: 1 hr 30 mins (30 miles) from Naples
Positano, Villa Rufolo, Emerald Grotto
Day 14: Rome
Estimated travel time/distance from previous location: 3 hrs (150 miles) from Amalfi Coast
Trevi Fountain, Spanish Steps, Vatican City
If you have more time,consider adding a day trip to Siena or visiting the Amalfi Coast's Ravello or Capri. If you have less time, consider skipping the Lake Como or the Amalfi Coast portion of the itinerary. Remember to book tickets for museums and attractions in advance to avoid long lines.