Begin your exploration of Panama City by stepping back into history in the country's oldest surviving neighborhood. Casco Viejo's UNESCO-protected streets are filled with baroque and neoclassical architecture, and it's a perfect place to start at the heart of the city's culture. The Panama Canal Museum is a must-visit attraction for those interested in the nation's history or the 50-mile canal that links the Pacific to the Atlantic.
Take a walk along the palm tree-lined Ciate Costera—a waterfront park that hugs the Panama coastline for two miles. This open-air attraction is perfect for anyone looking to enjoy beautiful views of the surrounding city skyline or getting some fresh sea air. Head to Paseo Las Bóvedas for a shopping excursion, where local artisans sell their crafts. You can also use this time to explore the Panama City beachfront's well-known bars and restaurants, such as La Rana Dorada.
For your final day in Panama City, head to the Financial District—the city's bustling and vibrant central business district. Start at Cinta Costera for a walk through the park, and then head to the contemporary Biomuseo to explore Panama's eco-diversity. The district's many restaurants—including the legendary El Trapiche, known for tasty local cuisine such as arroz con pollo (chicken and rice)—offer a chance to experience Panamanian urban lifestyle.
If you have an extra day, consider taking a visit to Panama Canal and enjoy the city's waterway systems' fascinating architecture. But if you have less time, it is advisable that you truncate half of each day itinerary but ensure you include Casco Viejo in your list.