Public transportation in Rome is fairly easy to use and cheap, with tickets for one ride costing €1.50. Taxis and Uber are also available, but they can be more expensive. Keep in mind that Rome is a walking city, so wear comfortable shoes and be prepared to explore on foot.
If you have more time, consider taking a day trip to one of the nearby towns like Tivoli or Ostia Antica. If you have less time, prioritize the places you want to visit and plan accordingly. Be sure to book tickets in advance for the Colosseum and Vatican Museums to avoid long lines.