Most destinations can be easily reached by car or public transportation. You can rent a car or hire a driver to visit Napa Valley and Yosemite National Park. Make sure to book your tickets in advance if you're planning to visit Alcatraz Island. Consider taking public transportation, such as BART and Muni or Uber, to avoid traffic and parking expenses, especially in heavily populated areas like San Francisco.
If you have more time, add a day to relax and explore the lesser-known neighborhoods in San Francisco, such as the Castro, Haight-Ashbury, and Mission District. You can also add a day trip to Monterey Bay or Big Sur. If you have less time, consider skipping Napa Valley and Lake Tahoe, and spending more time in San Francisco and Yosemite National Park.