Start your trip off in Milan at the famous Milan Cathedral, also known as the Duomo di Milano. This stunning gothic cathedral dates back to the 14th century and is the fifth-largest cathedral in the world. Take in the breathtaking views from the rooftop terrace and admire the intricate details of the architecture.
Immerse in Milan's art and history with visits to the Pinacoteca di Brera and the nearby Sforza Castle. Pinacoteca di Brera is home to an impressive collection of Italian art masterpieces from the 14th to the 20th century, including works from Caravaggio and Raphael. Then, move on to the Sforza Castle, a former fortress and now a museum that houses historic art pieces, including Michelangelo's last sculpture, the Rondanini Pietà.
Spend the day exploring Milan's world-famous fashion district, Quadrilatero della Moda, and indulge in some high-end shopping. Then, head to the Church of Santa Maria delle Grazie, where you can see one of the world's most famous artworks, Leonardo da Vinci's Last Supper (Cenacolo Vinciano). Be sure to book tickets for this must-see beauty well in advance.
Spend the day exploring Milan's hippest neighborhoods while admiring the boats that navigate the canals in the lively Navigli district. In the afternoon, visit Leonardo da Vinci's Vineyard (Vigna di Leonardo), which he acquired in 1498 under the patronage of Ludovico il Moro. Here, you'll find a small museum that explores the history of wine and winemaking with exhibits focused on the legacy of Leonardo.
End your trip with visits to Milan's iconic La Scala Opera House and the Galleria Vittorio Emanuele II shopping arcade. La Scala is a historic theater which opened in 1778 and has hosted some of operas' most famous musicians. Meanwhile, the Galleria Vittorio Emanuele II is one of the world's oldest and most beautiful shopping arcades, with luxury shops and cafes making it a delightful stop before finishing the trip.
Milan has an extensive public transportation system that includes buses, trams, and a subway network. Purchase a MilanoCard that provides access to public transport and many museums, discounts for tours and shopping, and more. Purchase a 24-hrs or 48-hrs pass depending on your needs. Taxi and car rental services are also available, but these are much more expensive and not really necessary for this itinerary.
If you have more time, consider scheduling a day trip to Lake Como or Bergamo. If you have less time, shorten your visit to museums or avoid some of Milan's districts. Take time to explore other gems Milan has to offer such as the Biblioteca Ambrosiana library, Orto Botanico di Brera botanical garden, and the Piazza Mercato antiques market.
Travelers arriving in Milan come to one of three airports, namely Malpensa (MXP), Linate (LIN), and Orio al Serio (BGY). Malpensa is Milan's main international airport, located at a distance of approximately 45 km (28 mi) northwest from Milan city center. Linate, located just 8 km (5 mi) from the city center, mainly caters to domestic and short-haul international flights. Meanwhile, Orio al Serio is the third airport serving Milan, which is situated at a distance of approximately 50 km (31 mi) from Milan and primarily serves low-cost airlines. Buses, trains, taxis, and car rentals are available for transfers to the city center from all three airports.