During your trip, you will need to consider flights, buses, taxis, and boats between locations. The total travel time will be approximately 35 hours, and the total cost will be roughly 500 USD per person.
If you have more time, consider visiting the beaches of Phuket, Thailand or the Mekong Delta in Vietnam. If you have less time, consider skipping Hanoi and spending more time in Bangkok or Ho Chi Minh City. Remember to pack light and bring comfortable clothing for hot and humid weather. Don't forget to bring a reusable water bottle to stay hydrated and reduce plastic waste.