Take an early high-speed train from Paris Gare de Lyon toward Roma Termini, allowing roughly 11–12 hours for the journey, including the change—usually in Milan or Turin, depending on the service. Book a single through itinerary if possible, and arrive at Gare de Lyon 30 minutes early for boarding. Once at Roma Termini, a taxi to your hotel is simplest with luggage; the fixed taxi fare to central Rome is generally around €50, while the Leonardo Express to Fiumicino Airport is not relevant unless your connection routes that way. After checking in and dropping bags, keep the evening on foot: Rome’s historic center is compact, but comfortable shoes are essential over the cobblestones.
Begin at Trevi Fountain, ideally after dusk when the crowds thin slightly and the stonework is beautifully lit; allow about 30 minutes, and approach via the quieter lanes around Via della Panetteria rather than expecting an empty basin. Walk about 15 minutes through the Centro Storico to the Pantheon, open until 7 p.m. on most days, with last entry usually 30 minutes before closing; admission is generally around €5, and respectful clothing is required because it remains a church. Continue another 10 minutes to Piazza Navona, where Bernini’s Fountain of the Four Rivers and the surrounding cafés make an easy, atmospheric first-night stroll. For dinner, reserve at Roscioli Salumeria con Cucina in Campo de’ Fiori—roughly a 10-minute walk from the piazza—for Roman classics, excellent cured meats, and pasta; expect about €35–60 per person, and book ahead because the dining room is small.
Start early at the Colosseum, ideally with a timed entry around 8:30–9:00 a.m. September is still busy, and arriving before the crowds and heat makes the 1.5-hour visit much more comfortable. A standard combined ticket covering the Colosseum, Roman Forum and Palatine Hill is generally around €18–25, with reservation fees added for timed entry; bring identification if your booking requires it. From Roma Termini, walk about 15 minutes or take Metro B one stop to Colosseo. After the amphitheater, continue directly into the Roman Forum and Palatine Hill for roughly two hours. Wear sturdy shoes, carry water, and allow extra time for uneven ancient paths—the best elevated views are around the Palatine terraces overlooking the Forum.
Walk into Monti for lunch and an easy neighborhood wander. Around Piazza della Madonna dei Monti, you will find independent boutiques, small galleries, and relaxed cafés; La Barrique is a good choice for a casual Roman lunch and wine, while Ai Tre Scalini works well for a light plate and local atmosphere. Allow about 1.5 hours rather than rushing—this is one of Rome’s nicest districts for simply turning down side streets. From Monti, walk approximately 15–20 minutes to the Capitoline Museums via Via dei Fori Imperiali and Piazza Venezia. Reserve a museum time if possible; allow two hours for the classical sculpture, Renaissance architecture, and the view toward the Forum from the Tabularium. Admission is usually about €15–20, and the museums generally close around 7:30 p.m., with last entry earlier.
After the museums, spend 30 minutes at Piazza Venezia, taking in the scale of the Vittoriano and the constant movement around Rome’s central crossroads. It is worth stepping slightly aside toward Via del Corso for a less hectic view before walking approximately 15 minutes to dinner at Armando al Pantheon. Book ahead—this traditional Roman trattoria is small and popular, and dinner service typically begins around 7:00 p.m. Expect approximately €35–55 per person; look for classics such as carbonara, amatriciana, or saltimbocca, depending on the day’s menu. The restaurant is closed on Sundays and may have seasonal schedule changes, so confirm the reservation and opening hours before setting out.
Take the planned early Frecciarossa from Rome and arrive at Firenze Santa Maria Novella around 9:00–9:30 a.m. The station is wonderfully central: walk about 15 minutes through the San Marco neighborhood to Galleria dell’Accademia, or use a short taxi ride if you have luggage. Allow roughly 1½ hours inside for Michelangelo’s David, the unfinished “Prisoners,” and the gallery’s Florentine sculpture collection. A timed ticket is strongly recommended; admission is usually around €16–€20, and the museum generally opens at 8:15 a.m. except Mondays.
From the Accademia, stroll south along Via Ricasoli toward Duomo di Firenze—about 10 minutes. Spend an hour admiring the cathedral interior and the exterior of the Baptistery and Giotto’s Campanile. The cathedral is free to enter, while the dome, bell tower, and other monuments require a paid combination pass; don’t try to add a dome climb today unless you have a reserved time slot. Continue for 8 minutes toward Mercato Centrale Firenze in San Lorenzo for lunch. Upstairs, you’ll find a lively food hall with options such as lampredotto, fresh pasta, pizza, and Tuscan crostini; budget €15–30 per person. It is busiest around 12:30–1:30 p.m., so arrive slightly early if you want a relaxed table.
After lunch, walk approximately 15 minutes through Via del Giglio and Piazza della Repubblica to the Uffizi Gallery in Signoria. Allow about 2½ hours for Botticelli, Leonardo, Michelangelo, and Caravaggio; with limited time, prioritize the Botticelli rooms and the gallery’s corridor overlooking the Arno. Your reserved entry time matters—late arrivals may be refused—and tickets commonly cost about €25–30 including reservation fees. The museum is usually open Tuesday through Sunday from 8:15 a.m. until 6:30–7:00 p.m., but confirm the exact September schedule when booking.
When you leave, wander through Piazza della Signoria and follow the river toward Ponte Vecchio, a 10-minute walk. Cross the bridge slowly in the early evening, when the light catches the Arno and the jewelry shops begin to glow. For dinner, continue into Oltrarno and look around the quieter streets near Santo Spirito; reserve ahead for a traditional trattoria, and keep the evening unhurried after the early train and museum-heavy day.
Take the planned regional train from Firenze Santa Maria Novella to Pisa Centrale, leaving around 8:00 a.m.; the ride takes about an hour and costs roughly €9–11. At Pisa Centrale, walk north for approximately 25 minutes through the historic center, or take a local bus toward Piazza dei Miracoli if you prefer to save your energy. Aim to reach the Leaning Tower of Pisa around 9:30–10:00 a.m. Its timed climb takes about 30–45 minutes, and advance tickets are strongly recommended; arrive at least 15 minutes before your slot, as bags must be left at the nearby cloakroom.
Continue directly to Pisa Cathedral and Baptistery, both within Piazza dei Miracoli, allowing around 1½ hours for the striped Pisan Romanesque architecture, intricate pulpit work, and the Baptistery’s famous acoustics. Cathedral entry is generally included with tower reservations, while standalone or combined tickets vary by visit and are best checked through the official site. Afterward, stroll down Via Santa Maria toward the river—this is the right place for a relaxed lunch, with simple Tuscan dishes, panini, and cafés rather than the more expensive restaurants immediately beside the square.
Walk south through the Santa Maria quarter to Palazzo Blu on Lungarno Gambacorti, roughly 15–20 minutes from the cathedral. The riverside route is pleasant and gives you a more lived-in view of Pisa after the monumental square; allow about 1½ hours inside for the rotating exhibitions and permanent collection. Opening days and exhibition hours can vary, but the museum commonly operates from late morning into the evening and may close on Mondays, so verify the September schedule before setting out. From Palazzo Blu, Osteria dei Cavalieri is about a 10-minute walk back through Santa Maria; reserve ahead if possible and expect around €25–45 per person for hearty Tuscan cooking. Order local pasta or a seasonal second course, then return to Pisa Centrale on foot in roughly 20 minutes or by bus if you are carrying luggage.
Take the planned morning train from Pisa Centrale to Venezia Santa Lucia, allowing roughly 4½–5½ hours including the connection. You should arrive around midday or early afternoon; the station opens directly onto the Grand Canal, so avoid taxis unless your accommodation is far from the center. Venice is easiest on foot, though a vaporetto ride is useful with luggage—buy a single ticket for about €9.50 or a 24-hour pass if you expect several rides. Leave bags at your hotel or a station-area luggage deposit before heading into San Polo.
Walk south through Strada Nova and across the quieter lanes toward Rialto Market, where the seafood and produce stalls are generally most active Monday–Saturday, roughly 7:30 a.m.–1:00 p.m.; some individual stalls may close earlier. Spend about an hour browsing the market and nearby Campo de la Pescaria, then cross the Rialto Bridge for the classic Grand Canal view. The bridge is free and busiest in the afternoon, so pause on the side platforms rather than blocking the central staircase. For a quick Venetian snack nearby, look for cicchetti—small bar snacks—around the lanes of San Polo, but keep lunch light since dinner is booked.
From Rialto Bridge, follow the signs toward St. Mark’s Square, a pleasant 15–20-minute walk through the narrow streets. Visit St. Mark’s Basilica in the late afternoon, checking the official timed-entry schedule when booking; modest clothing is required, and large bags must be left in the designated deposit area. Allow about an hour for the mosaics and interior, then continue directly to Doge’s Palace, where a timed ticket is strongly recommended. Set aside 1½ hours for the grand rooms, prisons, and Bridge of Sighs; the palace typically closes in the early evening, with final admission earlier, so do not leave these two visits until after dinner. From St. Mark’s Square, Osteria alle Testiere in Castello is about a 12–15-minute walk through quieter lanes. This tiny seafood restaurant costs approximately €50–80 per person, has very limited seating, and requires a reservation; arrive promptly for your booking and expect a focused, seasonal menu rather than a long leisurely meal.
Begin in Dorsoduro, walking from Venezia Santa Lucia across Ponte dell’Accademia and along the quieter canals toward the Peggy Guggenheim Collection. Reserve a timed ticket if available; the collection generally opens at 10:00 a.m., and allow about 1½ hours for Picasso, Dalí, Magritte, and the sculpture garden in the former Palazzo Venier dei Leoni. Tickets are typically around €18–20. From the museum, continue a few minutes to Punta della Dogana, the triangular customs-house building between the Grand Canal and lagoon. Allow roughly 45 minutes for the current contemporary-art exhibition, but check the official opening schedule before setting out, as exhibition hours can vary.
From Punta della Dogana, cross toward St. Mark’s Square and settle into Caffè Florian for coffee and a light pastry. This is deliberately a splurge—expect roughly €15–30 per person once the historic café’s table service and live-music surcharge are included—but it is a lovely final Venetian pause. Keep the stop to about 45 minutes, then collect your luggage and leave the historic center approximately 2½–3 hours before your flight. For Venice Marco Polo Airport, the most straightforward option is the Alilaguna airport boat from a nearby waterfront stop, taking roughly 1–1½ hours depending on the line; a private water taxi is much faster but considerably more expensive. Alternatively, walk or take a vaporetto to Piazzale Roma and use the ATVO airport coach, usually about 20–25 minutes once aboard. At Venice Marco Polo Airport, allow at least two hours for check-in, baggage drop, and security before your afternoon or evening flight to Paris; keep your passport and airline details accessible, and expect the final airport transfer from the center to be the least predictable part of the day.
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