Begin the day with a guided tour of the Vatican City, a 44-hectare city-state located within Rome known for its art and historical and religious significance. Visit landmarks such as St. Peter's Basilica and the Vatican Museums featuring the famous Sistine Chapel. Afterward, head to the Colosseum for a guided tour, including a visit to the Roman Forum and the Palatine Hill.
Begin the second day with a train ride to Florence, known for its art, architecture, and historical significance. Take a guided tour of the city, visiting landmarks like the Florence Cathedral, Ponte Vecchio, and Piazza della Signoria. Afterward, take a train to Pisa to see the world-famous Leaning Tower and Pisa Cathedral.
While in Rome, the most efficient mode of transportation is the Metro system, with a one-way ticket costing €1.50. Trains are the best option for traveling from Rome to other cities in Italy, with tickets priced anywhere between €10 to €30 one way, depending on the destination and timing.
If you have more time in Rome, consider visiting other landmarks such as the Trevi Fountain or the Pantheon. In Florence, the Uffizi Gallery and Accademia Gallery are must-visit art museums, but require half a day each for a proper visit. If you have less time, consider combining the Colosseum and Roman Forum tours in one day and skipping Pisa altogether.
Rome has two major airports: Leonardo da Vinci-Fiumicino Airport (FCO) located 19 miles southwest of the city center and Ciampino Airport (CIA) located 12 miles southeast of Rome. FCO is the main international airport for Rome, while CIA mostly serves European budget airlines. Florence has its own small airport, Amerigo Vespucci Airport (FLR), located just 3 miles northwest of the city center.