Start the trip with Vatican City, a city-state surrounded by Rome, famous for St. Peter's Basilica and the Sistine Chapel. Book a guided tour of the Vatican Museums to learn about the art, architecture and history of the Vatican.
Take a train to Florence, the birthplace of the Renaissance and home to some of the world's most renowned museums and architecture. Visit the Galleria degli Uffizi to see works from Michelangelo, Caravaggio and Leonardo Da Vinci and Don't miss the Duomo, a famous church with an iconic orange dome.
On the third day, drive to Siena, a vibrant medieval town with a whitewashed cathedral and lots of eateries. Take a stroll through the Piazza del Campo, one of the most popular destinations in the city where you can discover its bars, cafes, and cute shops.
Drive to Pompeii, a ruined ancient city that was buried under volcanic ash in 79 AD. Take a guided tour to learn about the history and architecture of this UNESCO World Heritage Site, with well-preserved villas, temples, and mosaics.
Hit the road and explore Amalfi Coast, a picturesque region famous for its colorful buildings, stunning landscapes, and incredible food. Walk along the scenic coastal paths to admire views of the Tyrrhenian Sea, and visit the beautiful towns of Positano and Ravello for the perfect cultural escape in Italy.
Drive back to Rome and explore the Roman ruins, including the Colosseum and the Roman Forum. Take a leisurely stroll around picturesque neighborhoods such as Trastevere and Monti, and sample local specialties such as gelato, pizza, and pasta before departing for the airport.
If you have more time, explore more of Rome, and check out the city's hidden gems such as the Appian Way, an ancient Roman road lined with tombs and churches. If you have less time, skip Siena and Pompeii. Alternatively, visiting Tuscany's wine country is another great option to immerse yourself deeper into Italian culture.